Examining the Potential of Focused Sound Waves in Treating Cocaine Addiction

Researchers are investigating whether concentrated sound waves can be used to alleviate cocaine dependence by altering brain cells. This groundbreaking study aims at the insula region of the brain, known to be instrumental in various forms of addiction.

The project has received a $5 million grant from the National Institutes of Health for this avant-garde methodology.

Scientists at UVA Health are delving into the possibility that directed sound waves could offer a solution to the rising problem of cocaine addiction across the country.

The research team has initiated a clinical study, considered the world’s first of its kind, to evaluate the efficacy of low-intensity focused ultrasound in modifying brain cells to diminish the craving for cocaine. This non-invasive technique aims sound waves specifically at the insula region of the brain, recognized to have a key role in several types of addiction. Should the trial yield positive results, it could herald a significant new instrument in the broader treatment of addiction.

Nassima Ait-Daoud Tiouririne, MD, serves as the director of UVA’s Center for Leading Edge Addiction Research (CLEAR).

“The findings from this study could potentially alter the manner in which certain patients perceive cocaine,” stated Nassima Ait-Daoud Tiouririne, MD, director of UVA’s Center for Leading Edge Addiction Research (CLEAR). “Imagine the potential of reversing the neurological alterations caused by drug consumption. This could revolutionize our comprehensive approach to treating addiction.”

The Escalating Crisis of Cocaine Dependency

Cocaine consumption in Virginia has shown a consistent increase over the past ten years, according to the researchers. Fatal overdoses surged by one-third from the year 2019 to 2020. These alarming trends have galvanized the UVA research team to seek inventive methods to curb the intense cravings for this highly addictive substance. Currently, there are no FDA-approved medications to assist individuals in quitting.

In this new study, the scientists at UVA will employ focused sound waves to delicately stimulate cells within the insula region. They aim to determine if this method induces chemical alterations in the brain that lower the cravings for cocaine. Previous studies have already established the insula’s significant role in cocaine cravings and the likelihood of relapse. Additionally, individuals who have suffered injuries to the insula have been able to cease smoking without experiencing cravings or relapse.

If the technique is proven to be both secure and effective, patients may soon be able to attend a straightforward outpatient session and leave with a reduced urge to consume cocaine.

“A positive outcome would bring us closer to devising safer, novel methods to treat addiction,” said Ait-Daoud Tiouririne, from UVA’s Department of Psychiatry and Neurobehavioral Sciences. “Addiction is a neurological disorder, and treatment should encompass non-invasive neuromodulation of the brain circuits initially responsible for the addiction.”

The study is presently open for enrollment to individuals aged 18 and above, diagnosed with cocaine use disorder, who are not actively seeking to quit. Further information about the study can be accessed at UVA CLEAR website.

The National Institute on Drug Abuse, under the National Institutes of Health, has extended a grant of $5 million to support the trial, identified as 1UG3DA054789-01A1.

Focused Ultrasound Research at UVA

This cocaine dependency study complements an extensive range of research activities ongoing at the University of Virginia School of Medicine, exploring the immense possibilities of focused ultrasound in the treatment of severe illnesses, from cancer to Alzheimer’s disease.

UVA has long been at the forefront in pioneering the applications of focused ultrasound for patient benefit. Earlier investigations led by Jeff Elias, MD, and his team at UVA have facilitated FDA approval for the use of high-intensity focused ultrasound in treating symptoms of Parkinson’s disease and essential tremor, a prevalent movement disorder.

Last year, the success of its ultrasound-centered endeavors encouraged UVA Health to inaugurate the world’s first center explicitly dedicated to integrating focused ultrasound with immunotherapy for enhanced cancer treatment. The researchers are optimistic that this combination will offer new avenues in the fight against various types of cancer, from breast cancer to brain tumors.

Frequently Asked Questions (FAQs) about Focused sound waves in treating cocaine addiction

More about Focused sound waves in treating cocaine addiction

• UVA CLEAR – Clinical Trial Information
• National Institutes of Health
• UVA Health Research Initiatives
• FDA – Focused Ultrasound Approvals