Dkk1 is a protein that plays an important role in the development and maintenance of the body’s tissues and organs. It is essential for the formation of new blood vessels, the growth and repair of existing ones, and the proper functioning of the immune system. Dkk1 is also involved in bone remodeling and regeneration.
Dkk1 was first discovered in 1993 by Dr. Andrew Viteri and his team at Stanford University School of Medicine. Since then, much research has been conducted on this protein and its many functions in the body. Dkk1 is produced by cells throughout the body, but its highest levels are found in the bone marrow, skin, kidney, liver, lung, and pancreas.
Dkk1 plays an important role in wound healing by stimulating angiogenesis (the growth of new blood vessels). It also promotes cell proliferation and migration, which are necessary for tissue repair. In addition, Dkk1 regulates immune responses to infection and injury. For example, it helps to orchestrate inflammatory responses by activating certain white blood cells.
In cancer patients, high levels of Dkk1 have been associated with poor prognosis and resistance to treatment. This is because Dkk1 promotes tumor growth and metastasis (spread). Therefore, inhibiting Dkk1 activity may be a promising strategy for treating cancer. In fact, several drugs that target DKK1 are currently being developed or tested in clinical trials