Ketamine’s Role in Swiftly Treating PTSD and Depression

by Tatsuya Nakamura
Ketamine PTSD Treatment

A new study highlighted in the Annals of Pharmacotherapy reveals the effectiveness of ketamine in quickly alleviating symptoms of PTSD and depression. Ketamine, primarily an anesthetic and sometimes abused, is gaining attention for its mental health treatment capabilities.

This groundbreaking study suggests that ketamine can efficiently mitigate symptoms of PTSD and depression, a notable advancement given the typically gradual impact of conventional PTSD therapies. However, optimal ketamine treatment frequency and dosage remain uncertain, and the risks linked to its misuse are significant.

According to a recent meta-analysis by our team, published in the Annals of Pharmacotherapy, ketamine can significantly decrease PTSD and depression symptoms within a day after its administration.

Ketamine, known for its use in anesthesia and occasional recreational misuse, is being increasingly researched for its potential in treating various mental health disorders.

Study Analysis and Results

Our analysis encompassed six randomized controlled trials with 259 patients suffering from moderate to severe PTSD. In these trials, approximately half of the participants received ketamine injections, while the others were administered saline or midazolam, a benzodiazepine and anesthetic agent.

Patients treated with ketamine experienced about a 25% reduction in PTSD symptoms at one day and one week post-treatment. However, with repeated injections over four weeks, the symptom reduction rate dropped to 12%. The alleviation of depression symptoms was more modest but still noteworthy.

In most trials, patients received a single ketamine injection, while in others, they had multiple injections at the same dose over two to four weeks. The initial injection’s benefits were consistent across studies, but the efficacy of additional doses over time remains unclear.

Generally, even a single dose of ketamine can offer rapid but modest benefits. The ideal regimen for maintaining these benefits through repeated ketamine administrations is yet to be established.

The Importance of Ketamine for PTSD

PTSD is a severe mental health condition where past traumas lead to flashbacks, nightmares, depressed mood, anxiety, and avoidance of trauma-related activities. PTSD patients are twice as likely to attempt suicide as the general population.

Around 13 million Americans experience PTSD annually, nearly 5% of the adult population. PTSD arises from traumatic experiences such as military combat, physical assaults, natural disasters, child and sexual abuse. Those with severe cases often lose about three and a half workdays each month due to symptoms or treatment.

Current PTSD Treatments and Ketamine’s Benefits

The preferred treatment for PTSD is trauma-focused psychotherapy, which helps patients recall, process, and react to traumatic memories. However, it can take weeks to show benefits, and not all patients respond.

In such cases, antidepressants like paroxetine, sertraline, and venlafaxine are suggested, either alone or alongside psychotherapy.

Unlike these treatments, which may take five to eight weeks to be effective, ketamine shows immediate results. However, the long-term reduction in PTSD and depression symptoms from ketamine is comparable to that of traditional antidepressants once they become effective.

Given the urgency in cases of severe PTSD, where suicidal thoughts may be present, the immediate symptom relief provided by ketamine can be crucial. It could serve as an interim solution until other therapies and antidepressants take effect.

Unanswered Questions and Cost Considerations

The frequency of ketamine injections for effective PTSD and depression treatment remains unclear. Determining the optimal dosage and treatment duration is essential, especially considering the cost of around $800 per injection.

Risks of Ketamine Misuse

Ketamine abuse is a significant concern. Ketamine obtained from unlicensed sources or online may not be FDA-approved, may be incorrectly dosed, expired, or counterfeit, possibly containing harmful substitutes like synthetic LSD. Such illegitimate products pose serious health risks, including potential fatality.

Authored by C. Michael White, Professor of Pharmacy Practice at the University of Connecticut.

Originally published in The Conversation.

Frequently Asked Questions (FAQs) about Ketamine PTSD Treatment

What is the main finding of the recent study on ketamine?

The study, published in the Annals of Pharmacotherapy, found that ketamine can rapidly reduce symptoms of PTSD and depression, often within a day of administration.

How does ketamine compare to traditional PTSD treatments?

Ketamine offers a faster onset of symptom relief compared to traditional PTSD treatments like psychotherapy and antidepressants, which can take several weeks to show benefits.

What are the risks associated with ketamine treatment?

The risks include potential misuse and abuse of ketamine, especially when obtained from unlicensed sources. There are also uncertainties regarding the optimal frequency and dosage for treatment.

How effective is ketamine in reducing PTSD symptoms?

Patients receiving ketamine injections saw a reduction of about 25% in PTSD symptoms at both one day and one week after therapy. However, the effectiveness decreased to 12% with repeated injections over four weeks.

Is ketamine a viable option for immediate PTSD and depression symptom relief?

Yes, ketamine can be an effective immediate treatment option for severe PTSD cases, especially where there is a risk of suicidal thoughts and traditional treatments haven’t taken effect yet.

What are the costs associated with ketamine treatment?

Ketamine treatment costs around $800 per injection, making the determination of the required dosage and frequency of treatment important for cost-effectiveness.

What is the significance of ketamine in treating PTSD?

Ketamine’s ability to provide rapid symptom relief is significant for PTSD patients, who often suffer from debilitating symptoms like flashbacks, nightmares, and anxiety, and are at higher suicide risk.

More about Ketamine PTSD Treatment

  • Annals of Pharmacotherapy Study on Ketamine
  • PTSD and Depression Treatment Advances
  • Risks of Ketamine Misuse
  • Comparing Ketamine to Traditional PTSD Treatments
  • Cost Analysis of Ketamine Treatment
  • Significance of Ketamine in Mental Health Care

You may also like


Mike Johnson November 18, 2023 - 3:11 pm

really interesting article about ketamine, didn’t know it was that effective for PTSD. But the cost seems pretty high, no?

Rachel Green November 18, 2023 - 11:32 pm

Wow, this could be a game changer for PTSD patients. Especially for those who don’t respond to traditional treatments. Good job on the research!

Kevin T November 19, 2023 - 8:41 am

is it just me or does the idea of using an anesthetic for mental health seem a bit, idk, risky? I mean, what about the long term effects?

Samantha R November 19, 2023 - 9:00 am

I’ve read somewhere that ketamine could be misused, the article kinda confirms it. gotta be careful with these things, right?


Leave a Comment

* By using this form you agree with the storage and handling of your data by this website.

SciTechPost is a web resource dedicated to providing up-to-date information on the fast-paced world of science and technology. Our mission is to make science and technology accessible to everyone through our platform, by bringing together experts, innovators, and academics to share their knowledge and experience.


Subscribe my Newsletter for new blog posts, tips & new photos. Let's stay updated!

© 2023 SciTechPost