Rethinking Cirrhosis Risk: Drinking Patterns Trump Volume in Liver Health

by Klaus Müller
Cirrhosis Risk Factors

Reconsidering Cirrhosis Risk: Drinking Habits Trump Alcohol Volume in Liver Health

Recent research suggests that the risk of developing alcohol-related cirrhosis is influenced by drinking patterns, genetic factors, and the presence of type-2 diabetes. This study underscores the importance of how and when alcohol is consumed, rather than solely focusing on the total quantity, in assessing the risk of liver disease.

According to a recent study conducted by UCL, the Royal Free Hospital, the University of Oxford, and the University of Cambridge, individuals who engage in binge drinking and possess specific genetic traits are six times more likely to develop alcohol-related cirrhosis.

Published on December 14 in the journal Nature Communications, this study is groundbreaking as it is the first to comprehensively examine how an individual’s drinking pattern, genetic makeup (determined by a polygenic risk score), and the presence of type-2 diabetes collectively impact their susceptibility to alcohol-related cirrhosis (ARC).

The crucial finding that the pattern of drinking holds greater significance than the sheer volume of alcohol consumption, especially when combined with genetic predisposition and diabetes, provides a more precise means of identifying those most at risk of liver disease.

Global Significance of Liver Disease

Liver disease is a major contributor to premature mortality worldwide, with 2-3% of the global population afflicted by cirrhosis (liver scarring) or liver-related illnesses. Alarmingly, since the advent of the COVID-19 pandemic, alcohol-related fatalities have surged by 20%.

Study Methodology and Discoveries

In this study, researchers analyzed data from 312,599 actively drinking adults within the UK Biobank cohort to assess the impact of drinking patterns, genetic predisposition, and type-2 diabetes on the likelihood of developing ARC.

A baseline hazard ratio (HR) of one was established using data from participants who adhered to daily drinking limits, had a low genetic predisposition to ARC, and were free of diabetes.

The results revealed that individuals who engaged in heavy binge drinking, defined as consuming 12 units of alcohol in a single day at some point during a week, were three times more likely to develop ARC. For those with a high genetic predisposition, the risk quadrupled, and for individuals with type-2 diabetes, the risk doubled.

Dr. Linda Ng Fat, a primary author of the study from UCL Epidemiology & Public Health, commented, “Many studies examining the link between liver disease and alcohol primarily focus on the quantity of alcohol consumed. We took a different approach by emphasizing drinking patterns, which proved to be a superior indicator of liver disease risk compared to volume alone. Another significant finding is that the more risk factors present, the higher the ‘excess risk’ due to their interplay.”

In cases where heavy binge drinking and a high genetic predisposition coexisted, the risk of developing ARC was six times greater than the baseline risk. The addition of type-2 diabetes further amplified this risk.

Dr. Gautam Mehta, a senior author of the study from UCL Division of Medicine and the Royal Free Hospital, added, “While genetics certainly plays a role, this research underscores that drinking pattern is also a critical factor. Our findings suggest, for instance, that consuming 21 units of alcohol over a few sessions is more detrimental than spreading it evenly over a week. Incorporating genetic information, which may become more prevalent in healthcare in the coming years, allows for even more precise risk prediction.”

Although polygenic risk scores are not yet widely used in clinical practice, they are expected to become a more common method for personalized disease risk assessment.

Concluding Thoughts and Implications

Dr. Steven Bell, a senior author of the study from the University of Cambridge, emphasized the urgency of addressing the escalating liver disease crisis, particularly alcohol-related fatalities since the onset of the COVID-19 pandemic. He noted that this study equips healthcare professionals with innovative tools to pinpoint individuals at the highest risk, enabling more effective interventions for those who stand to benefit the most.

Pamela Healy, Chief Executive of the British Liver Trust, highlighted the significance of this research in revealing that not only the quantity of alcohol consumed but also the manner in which it is consumed matters. She stressed the need for a comprehensive “alcohol strategy” in the UK, encompassing taxation, stricter controls on alcohol advertising and marketing, and increased awareness of the dangers of binge drinking, to address the rising alcohol consumption trend over the past two decades.

Frequently Asked Questions (FAQs) about Cirrhosis Risk Factors

What is the main finding of the study regarding cirrhosis risk?

The main finding of the study is that drinking patterns, genetic factors, and type-2 diabetes have a significant impact on the risk of developing alcohol-related cirrhosis (ARC). It emphasizes that how and when alcohol is consumed is more critical than the total amount.

What is considered heavy binge drinking in the study?

In the study, heavy binge drinking is defined as consuming 12 units of alcohol in a single day at some point during a week.

How much higher is the risk of ARC for those with a high genetic predisposition?

Individuals with a high genetic predisposition to ARC were found to have a four times higher risk of developing alcohol-related cirrhosis compared to those with a lower genetic predisposition.

What is the significance of including type-2 diabetes in the risk assessment?

The study found that individuals with type-2 diabetes have a two times higher risk of developing ARC. When combined with heavy binge drinking and a high genetic predisposition, the risk is even greater.

How can these findings be applied in healthcare?

These findings suggest that assessing an individual’s drinking pattern, genetic risk, and diabetes status can provide a more accurate prediction of their risk for ARC. This information may be used to develop personalized interventions and risk assessment strategies in healthcare.

What are the implications of this research for addressing liver disease?

This research highlights the importance of not only the quantity but also the manner of alcohol consumption in liver disease risk. It underscores the need for comprehensive strategies, including taxation, advertising controls, and awareness campaigns, to address the rising trend of alcohol-related liver disease.

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ScienceGeek555 December 28, 2023 - 6:32 am

12 units in a day = bad news. Genetix too! Need more research on this.

JoeSmith87 December 28, 2023 - 4:06 pm

wow, this stuff is importnt! drinkin habits rly matter for ur liver! genetix play big role 2. glad they did study.

BusinessPro2023 December 28, 2023 - 11:15 pm

Thx 4 sharing! Drnk patterns, genes, diabetes = cirrosis risk. Need 2 rethink drnk culture.


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